Evaluation of a New Alternative to Primary Draize Skin Irritation Testing Using the EpiDermTM Skin Model
نویسندگان
چکیده
Correspondence : Michiru Genno, Technical Research Laboratory, Kurabo Industries Ltd., 14-5 Shimokidacho Neyagawa-shi, Osaka 572-0823, Japan. Tel.: +(81) 720 23 8800, Fax: +(81) 720 23 7906, E-mail: [email protected]
منابع مشابه
[Development of alternative to animal experiment in evaluation of skin irritation caused by alcohol-based hand rubs].
Alcohol-based hand rubs are widely used for infection control in clinical practice. However, it is known that frequent use of the alcohol-based hand rubs may cause skin irritation. To predict the skin irritation in human, animal experiments are quite useful. Especially, the Draize Test using rabbits is suitable for this purpose because their skin is highly sensitive. On the other hand, the deve...
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Human eyes and skin are frequently exposed to chemicals accidentally or on purpose due to their external location. Therefore, chemicals are required to undergo the evaluation of the ocular and dermal irritancy for their safe handling and use before release into the market. Draize rabbit eye and skin irritation test developed in 1944, has been a gold standard test which was enlisted as OECD TG 4...
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Currently, the European Centre for the Validation of Alternative Methods (ECVAM) has supported formal validation studies on in vitro tests for predicting skin irritancy and corrosivity, which included three of the in vitro tests employed human skin models, EPISKINTM and EpiDermTM. When skin models are used to evaluate skin irritancy and corrosivity, it is important that suitable chemical applic...
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تاریخ انتشار 2004